Associazione Nazionale Medici Cardiologi Ospedalieri

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FROM SEA LEVEL TO 3647 METERS: EXPLORING THE HIGH-ALTITUDE CHALLENGE OF MAXIMAL EXERCISE AND PHYSIOLOGICAL ADAPTATION
Anno:
2026
Background : Individuals who reach high altitudes engage in strenuous physical activity that increases their oxygen demand in an environment where atmospheric oxygen availability is reduced and the body's ability to use it is compromised. These effects are influenced by hypoxia but also by adverse environmental conditions, such as…
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METABOLIC MODULATION BY SGLT2 INHIBITORS CANAGLIFLOZIN AND DAPAGLIFLOZIN: A NOVEL STRATEGY TO BALANCE ANTITUMOR EFFICACY AND CARDIOTOXICITY IN HER2-POSITIVE BREAST CANCER THERAPY
Anno:
2026
Background The clinical use of doxorubicin and trastuzumab in HER2-positive breast cancer is limited by significant cardiotoxicity. Sodium-glucose cotransporter 2 inhibitors (SGLT2is), such as canagliflozin and dapagliflozin, have demonstrated cardiovascular protection in diabetes and heart failure, and emerging evidence suggests potential antineoplastic activity. Whether SGLT2is can simultaneously enhance antitumor…
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A HIGH-RISK PREGNANCY IN HYPERTROPHIC CARDIOMYOPATHY: A CASE REPORT HIGHLIGHTING INTRAFAMILIAL PHENOTYPIC VARIABILITY AND MANAGEMENT CHALLENGES
Anno:
2026
Introduction Hypertrophic cardiomyopathy (HCM) is a genetically heterogeneous myocardial disease characterized by marked phenotypic variability, even among carriers of the same pathogenic mutation. Pregnancy in women with obstructive HCM represents a high-risk condition, particularly in the presence of severe left ventricular outflow tract (LVOT) obstruction and limited pharmacological options….
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EARLY PROGNOSTIC MARKERS IN CARDIOGENIC SHOCK: IMPLICATIONS FOR CLINICAL DECISION MAKING
Anno:
2026
Background: cardiogenic shock (CS) remains associated with high in-hospital mortality despite therapeutic advances. Early identification of patients at risk of deterioration is essential for timely escalation of therapy. Aims: the aim of this prospective observational study was to identify early markers of clinical deterioration associated with high in-hospital mortality,…
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SPECKLE-TRACKING–BASED STAGING OF EXTRA-VALVULAR CARDIAC DAMAGE IN DEGENERATIVE MITRAL REGURGITATION: PROGNOSTIC IMPLICATIONS
Anno:
2026
Aims : In asymptomatic patients with severe primary mitral regurgitation (MR), surgical referral is based on two-dimensional echocardiographic indices that often identify advanced myocardial injury. Speckle-tracking echocardiography (STE) may detect earlier, reversible dysfunction. This study evaluated whether a novel multi-chamber STE-based staging system of extra-valvular cardiac damage improves risk…
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“ABLATE AND PACE” NELLO SHOCK CARDIOGENO: STRATEGIA DI SALVATAGGIO MEDIANTE ABLAZIONE DEL NODO AV E CRT PER LA FIBRILLAZIONE ATRIALE REFRATTARIA
Anno:
2026
L'ablazione del nodo atrioventricolare (AVNA) associata alla stimolazione biventricolare (CRT) è una terapia raccomandata per il rate control nella fibrillazione atriale (FA) refrattaria. Questo studio valuta l'efficacia della strategia "ablate and pace" in pazienti con shock cardiogeno (CS), dove la tachicardia incontrollata aggrava il deterioramento emodinamico. Tra il 2018…
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PULMONARY VEIN RECONNECTION PATTERNS AT REDO ATRIAL FIBRILLATION ABLATION: A COMPARISON BETWEEN RADIOFREQUENCY AND PULSED FIELD ABLATION.
Anno:
2026
Introduction Pulmonary vein (PV) isolation durability is a major determinant of long-term success after atrial fibrillation (AF) ablation. Pulsed field ablation (PFA) has emerged as an alternative to radiofrequency (RF), potentially offering more homogeneous and durable lesions. However, real-world data comparing PV reconnection rates between these technologies at repeat…
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ORTHOPEDIC RED FLAGS AS PREDICTORS OF ADVANCED PHENOTYPE IN CARDIAC AMYLOIDOSIS: A RETROSPECTIVE ANALYSIS
Anno:
2026
Background: Cardiac amyloidosis (CA) is a systemic infiltrative disease often associated with musculoskeletal manifestations. Orthopedic "red flags" include carpal tunnel syndrome (CTS), lumbar spinal stenosis, and spontaneous rupture of the distal biceps tendon. While their role in early suspicion is established, the association between the presence of these orthopedic…
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SMALLER ATRIUM, BETTER RHYTHM: LEFT ATRIAL VOLUME REDUCTION AFTER HOCM SURGERY
Anno:
2026
Introduction: Atrial fibrillation (AF) in hypertrophic obstructive cardiomyopathy (HOCM) is a negative prognostic factor in patients undergoing surgical correction. A precursor sign of AF is an increase in indexed left atrial volume (iLAVol, ml/m 3 ). We aimed to analyze the impact of HOCM surgery on iLAVol and the…
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SGLT2 INHIBITOR DAPAGLIFLOZIN ATTENUATES CARDIOMYOCYTE INJURY INDUCED BY PI3KΑ-SELECTIVE INHIBITOR ALPELISIB AND FULVESTRANT UNDER HYPERGLYCEMIA
Anno:
2026
Background: PIK3CA mutations occur in approximately 40% of hormone receptor-positive (HR+)/HER2-negative (HER2−) breast cancers and are associated with endocrine resistance. The combination of the PI3Kα inhibitor alpelisib and fulvestrant significantly improves progression-free survival (PFS) in this patient population, as demonstrated by the SOLAR-1 trial. However, treatment-induced hyperglycemia, observed in…
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