CONGRESS ABSTRACT

A 27-year-old male was diagnosed at the age of 15 with sarcomeric hypertrophic obstructive cardiomyopathy (HOCM) (MYH-7 gene, variant c1816 G>A). No comorbidities. Patient underwent periodic follow-ups showing a predominant mid-ventricular obstruction with evolution in apical aneurysm. He was on beta-blockers. Due to massive septal hypertrophy (30 mm), extensive…

Introduction Acute left-sided abdominal pain radiated to the left shoulder due to splenic infarction can be confused with cardiogenic thoracic pain. Splenic infarction is frequently linked to infiltrative hematologic disorders, but it can be also related to cardioembolic events. We present the case of a patient admitted to cardiology ward…

  A 65-year-old female patient with a diagnosis of hypertrophic cardiomyopathy, identified following the sudden death of her 10-year-old daughter. The cardiomyopathy initially presented in an obstructive form, with a maximum gradient of 90 mmHg at the left ventricular outflow tract. Coronary angiography showed no significant coronary abnormalities. Since…

Inherited cardiac disorders encompass genetically diverse myocardial and electrical disturbances with substantial prognostic implications. This study investigated the genomic architecture and clinical manifestations of heritable cardiac conditions in a Southern Italian cohort of 363 families and 480 affected individuals. The phenotypic distribution showed predominance of structural myocardial disorders (69.95%)…

  Background Steroid-induced hypertrophic cardiomyopathy is a rare complication in children undergoing prolonged corticosteroid therapy. Although typically reported in preterm neonates, this case in a six-month-old infant without pre-existing cardiac conditions broadens current understanding of this condition, highlighting the importance of thorough diagnostic and therapeutic approaches.    Case Description…

Introduction Genetic testing identifies a pathogenic variant, typically involving sarcomeric genes, in about 40-60% of patients with Hypertrophic Cardiomyopathy (HCM). When no pathogenic variant is found, clinical presentation may differ from that of genetic-positive individuals. The aim of this study was to investigate clinical and demographic characteristics of HCM patients…

A 54-year-old male was diagnosed in 2018 with hypertrophic obstructive cardiomyopathy (HOCM); genetic test negative for Sarcomeric HCM mutations. No relevant comorbidities. Cardiac MRI revealed intramyocardial LGE in inferolateral, anterior and septal regions. He was receiving nadolol 80 mg once daily (o.d.) due to hemodynamically significant latent LVOT obstruction…

Introduction Hypertrophic cardiomyopathy (HCM) is a genetically driven myocardial disorder characterized by significant variability in clinical presentation and functional capacity (measured by peak oxygen consumption, pVO2). This study investigates the relationship between functional capacity and adverse events, focusing on rehospitalizations and progression to end-stage HCM. Methods 413 HCM p atients(46%…

Case Report: A 46-year-old male with hypertrophic obstructive cardiomyopathy (HOCM) due to a MYH7 mutation was diagnosed at age 30 through familial screening. Despite treatment with bisoprolol and disopyramide at maximum tolerated doses, the patient experienced persistent dyspnea with mild exertion. Investigations revealed characteristic ECG findings: pseudonecrosis Q waves in V1-V2, ST-segment elevation…