Cardiac implantable electronic device (CIED)-related infective endocarditis represents a diagnostic and therapeutic challenge, particularly in the presence of negative blood cultures. We report the case of a 60-year-old woman with a history of resuscitated cardiac arrest, idiopathic myelofibrosis, hypothyroidism, and implantable cardioverter-defibrillator (ICD) implantation, who was admitted for persistent…