Background & Study Aim. In patients with heart failure with reduced ejection fraction (HFrEF), the use of four main pharmacological classes is currently recommended: angiotensin receptor–neprilysin inhibitors (ARNI), preferred over angiotensin-converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB), beta-blockers, mineralocorticoid receptor antagonists (MRA), and sodium–glucose co-transporter 2 inhibitors…