Associazione Nazionale Medici Cardiologi Ospedalieri

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IMPACT OF BASELINE HEART FAILURE SEVERITY ON EFFICACY OF VUTRISIRAN IN PATIENTS WITH TRANSTHYRETIN AMYLOIDOSIS WITH CARDIOMYOPATHY IN THE HELIOS-B TRIAL: A SUBGROUP ANALYSIS
Anno:
2025
Background: In the phase 3 HELIOS-B trial (NCT04153149), vutrisiran reduced the risk of all-cause mortality (ACM) and recurrent cardiovascular (CV) events, and improved functional capacity and quality of life (QoL) vs placebo in patients with transthyretin amyloidosis with cardiomyopathy (ATTR-CM). Methods: This subgroup analysis assessed the effect of vutrisiran…
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Compassionate use program with mavacamten in patients with hypertrophic obstructive cardiomyopathy: first insights from a single-centre real world experience
Anno:
2025
Introduction: Mavacamten, a first-in-class cardiac myosin ATPase inhibitor used as second-line therapy for hypertrophic obstructive cardiomyopathy (HOCM),  became available in Italy in early 2024 under a compassionate use program.  Aim: To describe early experience of compassionate use of Mavacamten in a single centre HOCM population.  Methods: All patients had…
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Impact of genetic test results on clinical and instrumental characteristics in patients with hypertrophic cardiomyopathy: a single-centre retrospective analysis
Anno:
2025
Introduction Genetic testing identifies a pathogenic variant, typically involving sarcomeric genes, in about 40-60% of patients with Hypertrophic Cardiomyopathy (HCM). When no pathogenic variant is found, clinical presentation may differ from that of genetic-positive individuals. The aim of this study was to investigate clinical and demographic characteristics of HCM patients…
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TRANSIENT MOTOR APHASIA AND LEFT ENDOVENTRICULAR THROMBOSIS IN DUCHENNE MUSCULAR DYSTROPHY – DILATED CARDIOMYOPATHY
Anno:
2025
Duchenne muscular dystrophy (DMD) is a progressive myopathic disorder caused by a recessive mutation in the dystrophin gene on the X chromosome, that result in progressive skeletal muscle weakness as the main clinical manifestation. However, cardiac muscle is also affected. Dilated cardiomyopathy (DCM), arrhythmias, and congestive heart failure (HF)…
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Cardiac Amyloidosis Awareness among General Practitioners
Anno:
2025
Background: The incidence of cardiac amyloidosis (CA) is constantly rising. Studies on CA awareness among cardiologists, internal medicine specialists, and geriatricians have identified various gaps in physicians' knowledge. General practitioners (GPs) are often gatekeepers who may generate a suspicion and influence time to diagnosis. However, little is known about…
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KAWASAKI DISEASE AND OVERLAP WITH MACROPHAGE ACTIVATION SYNDROME PRESENTING AS MYOCARDITIS IN A TEENAGER
Anno:
2025
This report presents a case of a teenager with Kawasaki disease (KD) complicated by macrophage activation syndrome (MAS), an overlap condition presenting initially as myocarditis. The patient arrived with persistent fever, rash, and conjunctivitis, along with cardiac dysfunction marked by reduced ejection fraction on echocardiography and elevated cardiac laboratory markers…
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An uncommon cause of reversible cardiomyopathy
Anno:
2025
A 36-year-old patient presented to the emergency department of a spoke center in June 2022 with an episode of hypertension (200/100 mmHg). The patient underwent a cardiology evaluation and was started on antihypertensive therapy with angiotensin-converting enzyme (ACE) inhibitors and amlodipine. In June 2023, the patient was admitted to…
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Dramatic improvements of ECG abnormalities and NT pro BNP levels after treatment with cardiac myosin inhibitor in a case of hypertrophic obstructive cardiomyopathy
Anno:
2025
A 54-year-old male was diagnosed in 2018 with hypertrophic obstructive cardiomyopathy (HOCM); genetic test negative for Sarcomeric HCM mutations. No relevant comorbidities. Cardiac MRI revealed intramyocardial LGE in inferolateral, anterior and septal regions. He was receiving nadolol 80 mg once daily (o.d.) due to hemodynamically significant latent LVOT obstruction…
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A peculiar case of Takotsubo cardiomyopathy
Anno:
2025
We describe a case of a 77-year-old patient admitted to the Emergency department for sudden onset of headache, loss of consciousness with deviation of the buccal commissure and repeated vomiting. She was previously treated for breast cancer and her only known cardiovascular risk factor was hypercholesterolemia, currently managed with a rosuvastatine/ezetimibe combination….
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The Great Mimicker Unmasked: A Case Report of Cardiac Sarcoidosis Hidden by Myocardial Infarction and Colon Cancer
Anno:
2025
Sarcoidosis is a systemic disease in which a dysregulated immunologic response in genetically predisposed individuals leads to the formation of non-necrotizing inflammatory granulomas Cardiac involvement in sarcoidosis is usually associated with extracardiac sarcoidosis and can present as silent, minimally symptomatic, or clinically manifest.  A 44-year-old Caucasian male with an active lifestyle and…
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