Introduction: Managing heart failure at home is complex, particularly following an acute episode. Patients often struggle to adhere to the instructions received during hospitalization and experience anxiety during the transition to home care. This study aims to evaluate the feasibility and acceptability of a telephone-based nursing coaching intervention combined with home tele-monitoring. Materials and Methods: This multi-method study includes: I) A randomized controlled design involving 45 patients (≥65 years old) discharged with a diagnosis of acute heart failure. The intervention group will receive: 1) a pre-discharge educational session; 2) a six-month telephone coaching program; 3) home tele-monitoring of weight, blood pressure, heart rate, and oxygen saturation. Data sent to the nursing team will guide personalized interventions, potentially including reinforcement of self-care practices, specialist visits, or emergency service activation. II) A qualitative design with in-depth interviews to explore the experiences of patients receiving the intervention. Results and Conclusions: Recruitment began on September, 2024, and is ongoing. As of December 13, 2024, 22 patients have been enrolled (16 in the control group and 6 in the intervention group), with a mean age >80 years, predominantly female. The study results will provide insights into the feasibility of implementing this service, as recommended by the Medical Research Council, and will inform the design of future efficacy trials. This abstract is part of the NODES project, funded by the Italian Ministry of Universities and Research (MUR) under the M4C2 – Investment 1.5 "Innovation Ecosystems" program, within the National Recovery and Resilience Plan (PNRR), financed by the European Union – NextGenerationEU (Grant Agreement Code No. ECS00000036).