Introduction: secondary prevention in cardiovascular disease is essential to reduce the risk of recurrence and improve patient outcomes. The latest guidelines recommend a multidisciplinary, integrated approach involving multiple healthcare professionals. In this context, the Coronary Care Unit (CCU) nurse plays a key role in patient education, promotion of therapeutic adherence, and support in lifestyle modification, starting from the early stages of hospitalization. Objective: to implement a structured, multidisciplinary secondary prevention pathway, initiated upon clinical stabilization of the patient hospitalized in CCU, and continued throughout the first year after discharge. Methods: inclusion criteria: patients admitted to CCU for Acute Coronary Syndrome (ACS) presenting at least one modifiable risk factor (smoking, obesity/overweight, poor therapeutic adherence, substance abuse, sedentary lifestyle, or anxiety/stress). The pathway included: – identification of modifiable risk factors and patient consent; – targeted individual nursing counselling; – delivery of educational materials; – planning and implementation of multidisciplinary interventions based on identified risk factors (psychologist, dietitian, sociologist, addiction services); – telephone follow-up at 1, 3, 6, and 12 months post-discharge. Monitored indicators: therapeutic adherence, smoking cessation, physical activity, dietary habits, substance use, clinical parameters, and blood test values. Results: the project showed improved empowerment of both patients and caregivers, with positive effects on risk factor management and effective linkage between hospital and community-based services. Conclusions: lifestyle modification is a cornerstone of secondary prevention after ACS. The integration of a personalized, structured nursing pathway started during CCU hospitalization promotes healthy behaviors and improves cardiovascular prevention outcomes, enhancing quality of life after an acute cardiac event. The nurse’s intervention is a key element in ensuring continuity of care post-ACS.