CTLA-4 and PD-1 blocking agents affects longitudinal and radial strain in preclinical models, increases systemic CXCL12, cardiac fibronectin EDA, S-100 calgranulin, galectine-3 and NLRP-3/MyD-88/chemokine pathways
Anno:
2023
Background: Immune checkpoint inhibitors (ICIs) have significantly changed the oncology clinic in recent years, improving survival expectations in cancer patients. ICI therapy have a broad spectrum of side effects from endocrinopathies to cardiovascular diseases. In this study, pro-inflammatory and pro-fibrotic effects of short-term ICIs therapy in preclinical models were…