Associazione Nazionale Medici Cardiologi Ospedalieri

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A HEART OF STONE: A CASE OF APOLIPOPROTEIN A-I CARDIAC AMYLOIDOSIS TREATED WITH HEART TRANSPLANT
Anno:
2023
A 56-year-old woman was referred to our Unit for advanced heart failure refractory to pharmacological therapy with poor functional status (NYHA class IV, INTERMACS profile 4-5). She had a history of restrictive and hypokinetic cardiomyopathy secondary to autosomal dominant hereditary Apolipoprotein A-I (APOA1) amylodosis caused by Leu75Pro mutation, detected both in…
Heart Transplant in SARS-CoV2 positive Recipient: management protocol of world’s first case
Anno:
2023
During SARS-CoV2 pandemic, transplant programs had to devise strategies to deal with the possibility of COVID-19-positive donors and recipients. In March 2022, a 60-year-old man with dilated cardiomyopathy on the transplant waitlist was admitted to our Unit as a possible donation was presented. On arrival, he tested positive for…
PIRCHE (Predicted Indirectly Recognizable HLA Epitopes) algorithm as a possible predictor of AMR (antibody mediated rejection) following heart transplant, from lab experience to clinical practice: a case report
Anno:
2023
PIRCHE-II is an algorithm used to estimate the risk for developing alloreactivity towards HLA mismatches.  A 35-year-old man with idiopathic dilated cardiomyopathy with several previous hospitalizations for heart failure is admitted to our unit for a new episode in August 2021. After evaluation, the patient was placed on the…
Recurrent coronary artery vasospasm complicated by cardiac arrests in heart transplant recipient: an unusual enemy
Anno:
2023
Even if coronary vasospasm (CV) is considered a rare phenomenon in heart transplant (HT) recipients, during routine coronary angiography asymptomatic CV may be observed. We report the case of a 30-year-old male who underwent HT in 2007 for dilatative cardiomyopathy. He was maintained on tacrolimus and mycophenolate mofetil and…
A SUDDEN STROKE AFTER CORTICOSTEROID THERAPY FOR HEART TRANSPLANT REJECTION
Anno:
2023
After heart transplant, the immune system of recipient could recognise the transplanted heart as foreign and reject it. To avoid it, immunosuppressive therapy is used, but sometimes it is not enough, in these cases high doses of immunosuppressors must be used. If the rejection is cellular mediated the main therapy…