EFFICACY AND SAFETY OF GENOTYPE-GUIDED AND PLATELET FUNCTION TEST-GUIDED ANTI-P2Y12 THERAPY IN PATIENTS UNDERGOING PCI: A META-ANALYSIS OF RCTS
Anno:
2023
Clopidogrel is the most commonly used anti-P2Y12 drug in DAPT. Impaired pharmacological response and antithrombotic efficacy associated with cytochrome-P450 and/or ABCB1 gene mutations is observed in about 1/3 of treated patients. To circumvent this problem, guided therapy has been tested, based on either identification of predisposing gene mutations or results of platelet…