Associazione Nazionale Medici Cardiologi Ospedalieri

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CONGRESS ABSTRACT

CONGRESS ABSTRACT

Categorie
AN UNEXPECTED CARDIOGENIC SHOCK
Anno:
2023
Background. Chemotherapy regime based on 5-fluorouracil (5-FU) are frequently administered in the treatment of gastro-intestinal malignancies, especially colorectal carcinomas. A potential severe side effect of 5-FU is cardiotoxicity with often presents with chest pain related to coronary vasospasm. More serious cardiotoxicity, including dilated cardiomyopathy, ventricular arrhythmia and sudden cardiac…
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Dapagliflozin increases pAMPK and reduces myocardial and renal NF-kB expression in preclinical models of short-term doxorubicin cardiotoxicity through MYD-188 and NLRP3 pathways
Anno:
2023
Background: Doxorubicin-mediated adverse cardiovascular events are among the leading causes of morbidity and mortality in breast cancer patients. Sodium-glucose cotransporter 2 (SGLT2) inhibitors have recently been shown to be of therapeutic value in patients with type 2 diabetes, chronic kidney disease, and heart failure with reduced ejection fraction (HFrEF),…
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The effect of anthracycline chemotherapy on peak left atrial longitudinal strain: a metanalysis
Anno:
2023
Background: Currently there is a limited number of studies reporting atrial function, evaluated by peak left atrial longitudinal strain (PALS), among patients undergoing anthracycline chemotherapy. Objective: We investigated this issue through a meta-analysis of echocardiography studies that reported data on: A) PALS before and after anthracycline chemotherapy and B)…
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Combination of Spirulina, Ganoderma Lucidum and Moringa Oleifera improves cardiac functions and reduces pro-inflammatory biomarkers in preclinical models of short-term doxorubicin-mediated cardiotoxicity
Anno:
2023
Background: Anthracyclines are essential adjuvant therapies for a variety of cancers, particularly breast, and gastric and esophageal cancers. Whilst prolonging cancer-related survival, these agents can in-duce drug-related cardiotoxicity. Spirulina, Reishi (Ganoderma Lucidum) and Moringa are three nutaceuticals with anti-inflammatory effects that are currently used in cancer patients to improve quality…
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CTLA-4 and PD-1 blocking agents affects longitudinal and radial strain in preclinical models, increases systemic CXCL12, cardiac fibronectin EDA, S-100 calgranulin, galectine-3 and NLRP-3/MyD-88/chemokine pathways
Anno:
2023
Background: Immune checkpoint inhibitors (ICIs) have significantly changed the oncology clinic in recent years, improving survival expectations in cancer patients. ICI therapy have a broad spectrum of side effects from endocrinopathies to cardiovascular diseases. In this study, pro-inflammatory and pro-fibrotic effects of short-term ICIs therapy in preclinical models were…
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Berberine associated to Dapagliflozin exerts synergistic cardioprotective effects in cardiac cells exposed to the HER2-bloking agent Trastuzumab through pAMPK activation and reduction in Interleukin-6 levels
Anno:
2023
Background: Trastuzumab has improved the prognosis in patients with HER2-positive breast cancer, but it can induce left ventricular dysfunction with reduced ejection fraction or HF during treatment. Dapagliflozin is a SGLT2i with cardio-renal benefits. In the DAPA-HF (Dapagliflozin And Prevention of Adverse-outcomes in Heart Failure) trial, the sodium-glucose cotransporter…
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