CONGRESS ABSTRACT

Background: Combining anthracyclines and trastuzumab is highly effective in treating HER2-positive breast cancer but significantly increases the risk of cardiotoxicity. The sequential approach is often preferred, where anthracyclines are given first, followed by trastuzumab, with careful monitoring of heart function. Purpose: We report for the first time the cardioprotective…

Cardiac angiosarcoma is a rare endothelial cell tumor, the most common primary malignant tumor of the heart, characterized by an aggressive permeating growth within the surrounding myocardial wall. In most cases, it occurs in the right atrium and can infiltrate into neighboring structures and spread distantly. It is associated…

Background: Hyperglycemia and advanced glycation end products (AGES) are key players of heart failure and atherosclerosis in patients with/without cancer through the stimulation of pro-inflammatory signaling. GLP-1 receptor agonists exerts cardiorenal benefits in patients with/without diabetes, proposing themselves as a new cardioprotective strategy in a broad patient setting, including…

A 58-year-old woman with no prior cardiac history was diagnosed with HER2-negative metastatic gastric adenocarcinoma. She commenced chemoimmunotherapy with FOLFOX combined with nivolumab, an immune checkpoint inhibitor (ICI) targeting PD-1. After the second dose of nivolumab, she developed profound asthenia and myalgia. Laboratory investigations revealed marked elevations in creatine…

Background: Patients treated with 5-FU are exposed to high risk of acute chest pain, myocardial infarction, heart failure, arrhythmias, and sudden cardiac death. These patients need new cardioprotective strategies to reduce cardiovascular mortality. Vericiguat is a soluble guanylate cyclase (sGC) stimulator. It is used for the treatment of heart…

BACKGROUND. Human granulocyte colony stimulating factor (G-CSF) is a glycoprotein promoting neutrophilic bone marrow production. Its recombinant form is used to decrease chemotherapy related infection incidence or for hematopoietic stem cells (HSCs) mobilization in allogenic transplantation. Its most common adverse reactions are musculoskeletal pain and cephalea, whereas the most…

A 54-year-old female admitted to our Cardiology ICU due to acute abdominal pain radiating to the chest. The ECG showed sinus rhythm and flat T-waves in the infero-lateral leads. A TTE disclosed severe left ventricular dysfunction. Routine blood tests were performed: Troponin I: 1.05 → 1.02 ng/ml (normal reference…

Background: There's increasing evidence on the possible pro-atherogenic side effect of immune checkpoint inhibitors (ICIs) leading to an increased risk of atherosclerotic cardiovascular disease (ASCVD) in long-term treated patients. Methods: We retrospectively collected data on acute coronary syndrome (ACS) in active cancer patients receiving ICIs for more than 6…

A 71-year-old man with a family history of dilated cardiomyopathy (CMD) and a history of dual-chamber pacemaker implantation for sick sinus syndrome was diagnosed with HER2-positive metastatic adenocarcinoma of the distal esophagus. He was selected for treatment with FOLOFOX chemotherapy (CT) and Trastuzumab. Due to the potential cardiotoxicity associated…

Introduction: Emerging evidence suggests that patients with coronary artery disease carry an increased risk of cancer death. Methods: To assess the association between heart failure (HF) during hospitalization with acute coronary syndrome (ACS) and the very long-term cancer death risk, we enrolled 571 patients admitted with ACS to 3 Italian hospitals…