CONGRESS ABSTRACT

The role of nitric oxide (NO), soluble guanylate cyclase (sGC), and the cyclic guanosine monophosphate (cGMP) pathway in cardiovascular and renal health and disease is a complex issue. The impact of these biochemical pathways on the vascular tree is well established: the activation of sGC by NO promotes vasodilation…

Introduction Ischemic stroke (IS) is caused by the obstruction of cerebral blood vessels, resulting in reduced blood flow and impaired oxygen delivery. It can be caused by atherothrombotic occlusion of large arteries, cerebral embolism or non-thrombotic occlusion of small, deep cerebral arteries. Cardioembolic IS can occur in the presence…

Case Presentation: We report the case of a 63-year-old female with diagnosis of uterine leiomyosarcoma. Following total hysteroannessectomy, she commenced chemotherapy using a port-a-cath. A transthoracic echocardiogram revealed a 2 cm hyperechoic mass protruding into the right atrium. This finding was confirmed by transesophageal echocardiography, which identified the mass…

Background: Psychological stress has emerged as a significant non-traditional driver of cardiovascular disease (CVD). Despite its clinical relevance, the quantitative association between stress levels and objective hemodynamic markers in diverse patient populations remains to be fully elucidated. This study aimed to evaluate the relationship between perceived stress and blood…

Hyperkalemia is common in patients with chronic kidney disease (CKD) and heart failure (HF), often affecting prognosis and treatment continuity with renin–angiotensin–aldosterone system inhibitors (RAASi). Potassium (K⁺) binders allow control of K + serum levels and maintenance of RAASi therapy at proper dosage. Given the scarcity of real-world data…

Objectives. To identify clinical, radiological and echocardiographic features associated with indication to percutaneous patent foramen ovale (PFO) closure, with a specific focus on left-atrial functional indices, in a real-world cohort of patients with cryptogenic cerebrovascular ischemic event and PFO. Methods. In this single-centre retrospective study of 225 patients discussed…

Background: Cardiovascular diseases are a major global health concern, and statin therapy plays a pivotal role in both primary and secondary prevention. Statin-associated muscle symptoms are relatively common,whereas rhabdomyolysis remains a rare but potentially life-threating complication. Case presentation: We report the case of a 64-year-old male patient with a…

Background: Oral inhibitors of proprotein convertase subtilisin/kexin type 9 (PCSK9) represent a novel lipid-lowering strategy that may overcome limitations related to injectable therapies. However, the dose-specific efficacy and safety of this emerging drug class have not been comprehensively evaluated. Methods: We performed a systematic review and dose-stratified meta-analysis of…