Associazione Nazionale Medici Cardiologi Ospedalieri

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PLASMA TRANSTHYRETIN FORMS IN PATIENTS WITH WILD-TYPE TRANSTHYRETIN CARDIAC AMYLOIDOSIS: INFLUENCED OF TAFAMIDIS TREATMENT
Anno:
2023
Introduction. Transthyretin (TTR) is a plasma protein that transports thyroxin and retinol complexed to retinol-binding protein (RBP). TTR misfolding and aggregation can lead to the extracellular deposition of amyloid in the myocardium, causing TTR cardiac amyloidosis (ATTR-CA). Aim of this study is to develop a native electrophoretic method to…
Does cardiac amyloidosis ever hide a severe aortic stenosis A case report
Anno:
2023
Case presentation: A 89-year-old man, with an history of paroxysmal atrial fibrillation and chronic renal disease, was admitted to our ER for acute decompensated heart failure. He reported dyspnea on minimal exertion and worsening peripheral edema. He had a history of heart failure and a severe aortic stenosis first diagnosed in 2020…
Reduction in ejection and pre-ejection periods are predictive of mortality in AL and ATTR heart amyloidosis
Anno:
2023
Background: Amyloidosis is a systemic disease caused by fibrillary misfolded protein deposition in several organs including the heart. Cardiac deposition is the leading cause of death in these patients. Echocardiography is the imaging technique mostly used to study cardiac amyloidosis. Many studies tried to identify earlier markers to stratify…
DISCOVERY OF A NEW hATTR GENETIC VARIANT: A CASE REPORT OF A PATIENT WITH CARDIAC UPTAKE AT 99-MTC-DIPHOSPHONATES SCINTIGRAPHY AND ABNORMAL MONOCLONAL PROTEINS TESTS
Anno:
2023
INTRODUCTION Cardiac amyloidosis is an infiltrative disease that remains an under-diagnosticated cause of heart failure. Diagnostic algorithms focus on identifying the two most frequent forms of the disease, light chains amyloidosis (AL) and transthyretin amyloidosis (ATTR), by the initial use of 99mTc-DPD scintigraphy coupled to assessment of monoclonal proteins….