CONGRESS ABSTRACT

  BACKGROUND Tako-Tsubo syndrome (TTS) is characterized by reversible dysfunction of ventricular contractility and it’s associated with non-trivial rates of complications. Charlson Comorbidity Index (CCI) is a score to predict 10-year survival in patients with multiple comorbidities. We aimed to evaluate the usefulness of this score in predicting major complications during hospitalization of patients with TTS.   METHODS This is a retrospective observational single-center study that included 102 patients with TTS confirmed at echocardiographic follow-up. We evaluated: basic characteristics (age, sex), cardiovascular risk factors (current smoking, diabetes, dyslipidemia, hypertension, overweight), comorbidities (CCI, trigger event), initial clinical presentation (blood pressure, heart rate, Killip class), laboratory variables (C-reactive protein, creatin kinase, estimated glomerular filtration rate, hemoglobin, N-terminal prohormone of brain natriuretic peptide, platelets, white blood cells), and strumental variables (ejection fraction, form of TTS, QT interval, ST segment). The outcome was defined as the composite of cardiogenic shock, life-threatening arrhythmia, renal failure requiring dialysis, respiratory failure requiring orotracheal intubation, stroke (ischemic), and death from any cause.   RESULTS The composite outcome occurred in 11% of patients after a mean follow-up of 10 days, there were 5 in-hospital all-cause deaths. At univariate analysis, only the variables CCI (3 [1-4] vs. 7 [6-8], p < 0.001) and Killip class 3 or 4 (7% vs. 36.5%, p = 0.015) were found to differ significantly in patients without vs. with complication. At the analysis of these variables with logistic regression only CCI was found to be a predictor of major complications with a strong trend toward significance (OR 1.340 [0.997-1.802], p = 0.052), high specificity and negative predictive value, but low sensitivity and positive predictive value.   CONCLUSIONS Charlson Comorbidity Index may be a useful tool to predict uncomplicated cases bewteen patients with TTS.