Background: Heart failure is a leading cause of hospital readmissions worldwide, with significant clinical and economic burden. Rehospitalizations are often related to inadequate self-care, poor adherence to therapy, and insufficient patient education at discharge. Nursing interventions play a key role in addressing these factors through structured education, follow-up, and transitional care programs. Objective: To analyze the role of nursing interventions in reducing hospital readmissions among patients with heart failure through a narrative review of the current literature. Methods: A narrative review was conducted by searching major biomedical databases for studies published in the last two decades focusing on nurse-led interventions in heart failure care. The analysis included randomized controlled trials, systematic reviews, and integrative reviews evaluating educational programs, discharge planning, self-care support, and post-discharge follow-up led by nurses. Results: The literature consistently shows that nurse-led interventions are associated with a reduction in hospital readmissions and improved clinical outcomes. Structured educational programs enhance patients’ knowledge, self-care behaviors, and adherence to pharmacological and non-pharmacological treatment. Transitional care models, including discharge education, telephone follow-up, and home visits, demonstrate a significant impact on continuity of care and early identification of clinical deterioration. Multidisciplinary approaches coordinated by nursing professionals further contribute to improved quality of life and reduced healthcare utilization. Conclusions: Nursing interventions represent an essential component in the management of patients with heart failure and are effective in reducing rehospitalizations. Integrating structured nurse-led education and follow-up programs into routine clinical practice may improve patient outcomes and optimize healthcare resources. Further research is warranted to standardize interventions and evaluate their long-term effectiveness