Associazione Nazionale Medici Cardiologi Ospedalieri

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POOR GLYCEMIC CONTROL IS ASSOCIATED WITH ELEVATED LEVELS OF CIRCULATING AMYLOID BETA 1-40 IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
Anno:
2024
Background: Recent evidence correlates Alzheimer ‘s disease (AD) and diabetes mellitus (DM), through the involvement of reduced insulin-like growth factor (IGF-1). In acute myocardial infarction (AMI), low IGF-1 levels are correlated with a high risk of mortality and re-infarction. However, the DM-amyloid 1-40 (Aβ1-40) association in patients with coronary…
ECG screening for cardiovascular disease in endurance athletes over 40
Anno:
2024
Introduction Cardiovascular diseases (CVD) increase with age. There are many athletes aged >40 years who practise endurance sports, that involve very high intensity physical exertion and prolonged efforts. This population undergo to annual examination with a medical history, spirometry, urine test and exercise test. CV and sudden cardiac death…
AORTIC REGURGITATION INDEX IDENTIFIES SIGNIFICANT AORTIC REGURGITATION DURING IMPELLA SUPPORT FOR CARDIOGENIC SHOCK
Anno:
2024
Background Aortic regurgitation (AR) significantly hampers the unloading effect and the antegrade flow enhancement expected from the micro-axial flow pump Impella (Abiomed, Danvers). To date, no dedicated hemodynamic index is available to inform on the severity of AR during Impella support. Methods We included 100 patients receiving Impella support…
CARDIAC CT-PERFUSION IMAGING IN MYOCARDIAL BRIDGING EVALUATION: A NOVEL WEAPON FOR NON-INVASIVE ASSESSMENT OF A SILENT KILLER
Anno:
2024
INTRODUCTION: Myocardial bridging (MB) is a congenital anomaly characterized by the intramyocardial course of one or more coronary arteries that provokes endothelial dysfunction and can generate myocardial ischemia with its pathological consequences. Because of the dynamic nature of the ischemic mechanism, a high-sensitivity myocardial perfusion stress test is often…
Repolarization gradient causes local depolarization abnormalities in Brugada Syndrome
Anno:
2024
Background:Transmural voltage gradient in RVOT induces ECG-phenotype in Brugada syndrome(BrS). Moreover,RVOT depolarization abnormalities have been described as contributors to BrS phenotype and arrhythmogenesis. Purpose:To investigate the effect of ajmaline administration on J-elevation of RVOT unipolar signals in BrS patients. Moreover,we wanted to assess whether ajmaline-induced unipolar J-point elevation variations…
Efficacy of Colchicine in addition to Anakinra in patients with Recurrent Pericarditis
Anno:
2024
Aim. Anakinra, an anti IL-1 agent targeting IL-1 alfa and beta, is available for the treatment of recurrent pericarditis in cases with corticosteroid dependence and colchicine resistance after failure of conventional therapies. However, it is unclear if the combination with colchicine, a non-specific inhibitor of the inflammasome targeting the…
Post-Endocarditis Mobile Thrombus in Pulmonary Valve: A Unique Case Report of Acute Pulmonary Embolism
Anno:
2024
Background: Infective endocarditis results from a complex interplay among bacterial virulence factors, coagulation, and hemodynamics.Native pulmonary valve endocarditis is a very rare phenomenon. Similarly, the development of a thrombus on the pulmonary valve is uncommon. In the following clinical case, these two rare events appear interconnected. Clinical Case: A…
INDEPENDENT EFFECT OF SGLT2i ON DIASTOLIC FUNCTION IN HFrEF POPULATION
Anno:
2024
Background: Scientific literature reinforces the role of diastolic dysfunction in patients with heart failure with reduced ejection fraction (HFrEF) as an independent prognostic indicator of all-cause mortality. In this context, E/e’ ratio plays a central role in diastolic dysfunction assessments and diagnosis. Despite the introduction of several novel medical…
ROLE OF CORONARY CT IN THE EMERGENCY ROOM IN THE PATIENTS WITH CHEST PAIN
Anno:
2024
OBJECTIVE Assess the use of Coronary CT in patients attending the emergency room (ED) with chest pain and/or doubtful signs/symptoms of acute coronary syndrome (ACS). BACKGROUND: Patients coming to the ED for chest pain are an important challenge. According to the guidelines (ESC 2023) it is necessary a fast…
Primary Results from APOLLO-B Open-label Extension Study of Patisiran in Patients with Transthyretin Cardiac Amyloidosis
Anno:
2024
Introduction: The Phase 3, placebo-controlled APOLLO-B study (NCT03997383) is evaluating the efficacy and safety of patisiran in patients (pts) with ATTR cardiac amyloidosis in a 12-month (M) double-blind (DB) period followed by an open-label extension (OLE) period when all pts receive patisiran. During the DB period, patisiran demonstrated statistically…