Associazione Nazionale Medici Cardiologi Ospedalieri

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CONGRESS ABSTRACT

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PRIMARY RESULTS FROM APOLLO-B, A PHASE 3 STUDY OF PATISIRAN IN PATIENTS WITH TRANSTHYRETIN-MEDIATED AMYLOIDOSIS WITH CARDIOMYOPATHY
Anno:
2023
Introduction: Transthyretin-mediated (ATTR) amyloidosis is a progressive, multisystem, fatal disease. Patisiran, an IV RNAi therapeutic, is approved for the treatment of hereditary ATTR amyloidosis with polyneuropathy. The safety and efficacy of patisiran in patients with wild-type or hereditary ATTR amyloidosis with cardiomyopathy (CM) is being investigated in the ongoing…
AMILOIDOSI CARDIACA DA TRANSTIRETINA NEL PAZIENTE ANZIANO: SEMPRE UNA FORMA WILD TYPE?
Anno:
2023
Background: L’amiloidosi da transtiretina (ATTR) esiste in due forme: una forma genetica trasmessa con eredità autosomica dominante (ATTRv) e una forma “wild type” (ATTRwt). Clinicamente la forma ereditaria tende ad avere un esordio precoce in età adulta e si caratterizza per un tropismo particolare per il tessuto nervoso oltre…
Reduction in ejection and pre-ejection periods are predictive of mortality in AL and ATTR heart amyloidosis
Anno:
2023
Background: Amyloidosis is a systemic disease caused by fibrillary misfolded protein deposition in several organs including the heart. Cardiac deposition is the leading cause of death in these patients. Echocardiography is the imaging technique mostly used to study cardiac amyloidosis. Many studies tried to identify earlier markers to stratify…
Prevalence and clinical significance of right ventricular pulmonary arterial uncoupling in cardiac amyloidosis
Anno:
2023
Background: This study aims to evaluate the prevalence and clinical significance of the right ventricular pulmonary arterial (RV-PA) uncoupling in patients with cardiac amyloidosis (CA). Methods: The study population consisted in 92 consecutive patients with CA (age 71.1±12.2 years, 71% males; 47% with immunoglobulin light chain (AL), 53% with…
CHALLENGING DIAGNOSIS OF A TRIPLE CARDIAC PATHOLOGY: TRANSTHYRETIN AMYLOIDOSIS WITH ASPECTS OF HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY AND ANOMALOUS CORONARY ARTERY.
Anno:
2023
A 70 years-old man with a history of systemic hypertension and surgically treated bilateral carpal tunnel was referred for dyspnea on exertion for few months. At physical examination a systolic heart murmur exacerbated by Valsalva maneuver was appreciated; no signs of heart failure. EKG with low-voltage QRS is shown…